美国医学科技是真的神奇，最近几大药厂在减肥药上都有重要突破
本人作为chronic 肥宅 （常年BMI30+），断断续续试着减肥了许多次，体重虽然不在最高点，但也一直保持在健康线以上，运动对于肌肉和cardio感觉比较好但还是很难控制食欲。最近试着打了ozempic （跟下列文章的wegovy是同一个active ingredient，唯一区别是剂量），感觉结果甚好，最低药量也能基本食欲维持在之前2/3左右，体重开始缓慢下降，最近医生推荐开始加大剂量。目前为止0副作用，但听说最大剂量有人犯恶心腹泻，作为药感觉算副作用最轻的了。
这类药（GLP-1）本身效果和安全性都比较有保障，在Diabetes II患者上也已经有小十年的历史，如果泥潭里面有相关专家欢迎补充。
唯一问题就是out of pocket 很贵 （900+），然后保险有可能不因为减肥原因cover （毕竟主流还是有糖尿病或者糖尿病风险的人使用），建议和医生聊聊（是处方药）。
使用方法是每周肚子或者腿打一针，针很小基本没什么感觉
EDIT:
有不少人问机理，这个我确实也没办法解释清楚因为0相关背景。只能说目前个人感觉有用，然后authorization本身实验结果上来讲对于weight loss very effective in a statistically significant way. Feel free to ask a doctor or consult medical resources.
These drugs mimic the action of a hormone called glucagon-like peptide 1. When blood sugar levels start to rise after someone eats, these drugs stimulate the body to produce more insulin. The extra insulin helps lower blood sugar levels.
Lower blood sugar levels are helpful for controlling type 2 diabetes. But it’s not clear how the GLP-1 drugs lead to weight loss. Doctors do know that GLP-1s appear to help curb hunger. These drugs also slow the movement of food from the stomach into the small intestine. As a result, you may feel full faster and longer, so you eat less.
Along with helping to control blood sugar and boost weight loss, GLP-1s and SGLT-2 inhibitors seem to have other major benefits. Research has found that some drugs in these groups may lower the risk of heart disease, such as heart failure, stroke and kidney disease. People taking these drugs have seen their blood pressure and cholesterol levels improve. But it’s not clear whether these benefits are from the drug or the weight loss.
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9/6 更新一下
最近因为保险不cover ozempic，发现最强神药eli lilly的tirpazide (mounjaro) 竟然有到明年的25$ savings program，已经找医生上车了
