看了那个美国枪战太多就要全家搬到欧洲去的帖子，再想起小红书天天讲美国人的松弛感，我想说其实这种紧张感很多时候是基因决定的，就讲Serotonin transporter 里面有个区域有种polymorphism 有长allele和短allele。东亚人短allele占大多数而白人长allele 占大多数。短allele的人就是不太行容易焦虑怕死。很多时候在倾听自己的感受的同时，要记得自己的gene conditioned us to feel like this way.
Individuals carrying the S allele of the 5-HTTLPR produce significantly less 5-HTT mRNA and protein, resulting in higher concentrations of serotonin in the synaptic cleft relative to individuals carrying the L allele (Lesch et al. 1996). Evidence from behavioural genetics indicates that the S allele of the serotonin transporter gene (5-HTTLPR) is associated with increased negative emotion, including heightened anxiety (Sen et al. 2004; Munafò et al. 2005), harm avoidance (Munafò et al. 2005), fear conditioning (Lonsdorf et al. 2009), attentional bias to negative information as well as increased risk for depression in the presence of environmental risk factors (Caspi et al. 2003; Taylor et al. 2006; Uher & McGuffin 2008; see also Munafò et al. 2009). In particular, exposure to chronic life stress, such as interpersonal conflict, loss or threat, is considered a well-known environmental risk factor for depression in S allele carriers of the 5-HTT (Caspi et al. 2003; see also Risch et al. 2009).
